Better - Less - Research

Growth hormone / IGF-1, which has been linked to longevity in animals, has also been linked to human longevity, according to recent research.

Previously, scientists from different countries noted that mice with a lack of GH or receptors for it age more slowly due to the better functioning of the insulin signal chain and increased resistance to stress. Consequently, evolutionary selection in favor of large, strong individuals capable of early reproduction often turned into negative consequences for these individuals in the post-reproductive period. By old age, they were more ill, many had died earlier.

But if the increase in the life span of various animals against the background of GH deficiency or resistance has already been proven in many experiments, then research on humans has become a new word in science.

The Leiden Longevity Study is based on the study of GH and IGF-1 in long-lived families and control groups (fathers / children and similar age participants with approximately equal numbers of men and women). The result showed that under the same conditions (ecology, nutrition, physical activity, etc.), subjects with a deficiency of receptors for GH did not have obesity, diabetes mellitus, and cerebrovascular accident. That is, GH resistance was directly related to protection against certain age-related diseases.

Moreover, this feature was inherited. And the offspring of participants with GH deficiency also had a high probability of a similar deficiency, and therefore a great chance in old age not to get sick with "typical" ailments.

Based on materials from the sites nestarenie.ru, moscowuniversityclub.ru and onlinelibrary.wiley.com/doi/10.1111/acel.12519/full